The Science - Ferulant

Ferulant is registered as a therapeutic preparation in Hungary and so in the European Community. Its proprietary composition was developed and patented in the USA.

Ferulant For Men were developed based on published scientific literature on nutritional components that benefit fertility and have a safe history of usage. The exact product that has been taken to market, has been scientifically studied in a direct study. Westphal and coworkers have determine the effects of this proprietary nutritional supplement in the USA at the Stanford University School of Medicine. Later efficacy of the product was tested in Hungary in a clinical trial. Ferulant was regisgtered as a curing drug in Hungary by the Hungarian authorities OGYI.

A pilot study was initiated to determine the effects of a proprietary nutritional supplement containing L-carnitine, green tea and Dong quai extracts, vitamins C, E, B6, B12 and folate, zinc and selenium. Changes in sperm count, motility, linearity and incidence of side effects were monitored.

Results: Forty-three (43) men, age 30-58 years, who were initially low in sperm count (<50 M/ml) or motility (<60%), and who had tried unsuccessfully to impregnate spouse for 6-36 months, completed the study. After 3 months, the supplement group (N=21) demonstrated an increase in mean sperm count from 23.2 M/ml initially, to 36.1 M/ml (55% increase, p=0.05). Motility increased from 29.6% to 39.5% after 3 months supplementation (33% increase, p=0.05). The treatment group also showed higher sperm linearity than the placebo group at 3 months (61.1 v. 52.6, respectively; p=0.04). The placebo group (N=22) demonstrated no significant improvement in any of these parameters. No serious side effects were noted.

Conclusion: This dietary supplement is an attractive option for use in the management and optimization of reproductive health in men, either by itself or as an adjunct to other fertility treatments.

Westphal L, Stanford Univ, Clin Res, 2007.

Effect of new dietary supplement on sperm quality

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods:In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment.Conclusions: This new dietary supplement may contribute to the treatment of male infertility.

Orv. Hetil., 2012,153, 1787–1792.

About the ingredients of FERULANT

· The amino acid, L-carnitine, has been shown to be critical to the formation of healthy sperm.

· Vitamins C and E, green tea and seleniumare all potent antioxidants that help improve sperm counts and quality.

· The antioxidant ferulic acid is found in Dong Quai, has also been shown to improve sperm quality.

· Based on an American patent and clinical studies at Stanford University, clinical testing of Ferulant, a therapeutical product aiding male infertility, was initiated and executed in Hungary (published in Orv.Hetilap 2012). Based on these encouraging results and consumer experiences together with a dietary supplement, Ovant, helping conception for women, Pharmaforte is a research leader in the field supporting fertility and healthy reproduction in the European Community.

· Ingredients zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for several benefits, including hormone metabolism, sperm formation and motility.

References:

· Costa M, et al. 1994. L-carnitine in ideopathic asthenospermia: a multicenter study. Andrologia 26:155-9.

· Zheng R-L and Zhang H. 1997. Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides. Free Rad Biol & Med 22(4):581-6.

· Kessopoulou E, et al. 1995. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil & Steril 64(4):825-31.

· Geva E, et al. 1996. The effect of antioxidant treatment on human spermatazoa and fertilization rate in an in vitro fertilization program. Fertil & Steril 66(3):430-4.

· Dawson EB, et al. 1992. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil & Steril 58(5):1034-9.

· Scott R, et al. 1998. The effect of oral selenium supplementation on human sperm motility. Br J Urol 82:76-80.

· Moriyama H, et al. 1987. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hin Kiyo 33(1):151-6.

· Takihara H, et al. 1987. Zinc sulphate therapy for infertile male with or without varicocelectomy. Urol 29(6):638-41.

· Czeizel AE. 1998. Periconceptual folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

Westphal L, Stanford Univ, Clin Res, 2007.
Horvath MM, Czeizel AE, Orv. Hetil, 2012, 153,1787-1792